Laurie Grove, Ph.D.
Ph.D. Chemistry, University of Wisconsin-Madison (2008)
B.S. Major in Chemistry, Minor in Mathematics, Pennsylvania State University (2003)
Dr. Grove came to Wentworth in 2009. Her academic interests span the fields of chemistry and biology. As an undergraduate student at Penn State she investigated the reaction mechanism of palladium-catalyzed carbon reduction reactions. After earning her B.S. in chemistry, she completed a Ph.D. in chemistry, with a specialization in inorganic chemistry, at the University of Wisconsin-Madison. For her dissertation work, she investigated the reaction mechanism of the metalloenzymes, iron and manganese superoxide dismutase. Dr. Grove’s technical specialties include absorption spectroscopy, magnetic circular dichroism spectroscopy, resonance Raman spectroscopy, and advanced DFT methods, including coupled quantum mechanics/molecular mechanics calculations. More recently, Dr. Grove has collaborated with the Structural Bioinformatics lab at Boston University to work on projects in protein modelling.
Courses Taught: Engineering Chemistry (Chem 1100), Biochemistry (Chem 3800), and Cellular and Molecular Biology (Biol 1100)
Dr. Grove enjoys working with students on a variety of projects in the fields of chemistry and biochemistry. She welcomes students to work on a project in the field of her own research interests or for students to propose their own projects. Student projects typically involve lab and safety training with the goals of achieving student independence and training in experiment design. Students also participate in weekly research meetings. Their projects culminate in the dissemination of their work, either at the campus, local, or national level. In addition to undergraduate research, Dr. Grove advises the Student Association of Biomedical Sciences.
Dr. Grove has also worked with many students on service learning projects and mentored students pursuing the Certificate in Community Learning (https://wit.edu/clp/certificate-community-learning). Her past community partnerships include various science outreach activities in conjunction with Sociedad Latina and working with the Mission Hill Neighborhood Housing Services to develop the first Wentworth Faculty and Staff Service Day.
- Grove, L. E., Vajda, S., Kozakov, D. Computational aspects of FBDD in Fragment-based drug discovery – Lessons and Outlook, Erlanson, D. A. and Jahnke, W., Eds.; Wiley, 2016.
- Kozakov, D., Grove, L. E., Hall, D. R., Bohnuud, T., Mottarella, S., Luo, Lingqi, Xia, B. Beglov, D., Vajda, S. The FTMap family of web servers for determining and characterizing ligand binding hot spots of proteins, Nature Protocols, 2015, 10, 733-755.
- Grove, L. E., Hall, D. R., Beglov, D. R., Vajda, S., Kozakov, S. FTFlex: Accounting for binding site flexibility to improve fragment-based identification of druggable ‘hot spots,’ Bioinformatics, 2013, 29, 1218-1219.
- Grove, L. E., Brunold, T. C. Second Sphere Redox Tuning of the Metal Ion Reduction Potential in Iron and Manganese Superoxide Dismutases, Comments on Inorganic Chemistry 2008, 29, 134-168.
- Grove, L. E., Xie, J., Yikilmaz, E., Karapetyan, A., Miller, A.-F., Brunold, T. C. Spectroscopic and Computational Insights into Second-Sphere Amino-Acid Tuning of Substrate Analogue/Active-Site Interactions in Iron(III) Superoxide Dismutase, Inorganic Chemistry 2008, 47, 3993-4004.